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Check out with the overall health care professional if any of the following Negative effects carry on or are bothersome or When you've got any questions about them:

Skin and subcutaneous tissue Ailments: allergic reactions like pores and skin rashes, urticaria, pruritus, sweating and facial oedema. Musculoskeletal and connective tissue Issues: Uncontrolled muscle movements. Muscle rigidity may come about soon after superior doses.

The individuals should be adopted carefully for indicators and signs of respiratory melancholy and sedation. In this particular regard, it truly is strongly proposed to inform individuals as well as their caregivers to concentrate on these signs and symptoms (see segment four.five).

Normal use through pregnancy might induce drug dependence during the foetus, resulting in withdrawal signs or symptoms in the neonate.

Children using this genetic variation who were being prescribed codeine right after tonsillectomy and/or adenoidectomy for obstructive sleep apnea might be at greatest danger based upon experiences of numerous deaths In this particular inhabitants resulting from respiratory despair. Codeine-made up of merchandise are contraindicated in all children who endure tonsillectomy and/or adenoidectomy. Suggest caregivers of kids getting codeine-made up of products and solutions for other motives to observe for indications of respiratory despair.

Codeine-containing merchandise are contraindicated for postoperative discomfort administration more info in little ones who definitely have been through tonsillectomy and/or adenoidectomy.

Domperidone and metoclopramide: codeine antagonises the result of cisapride, metoclopramide and domperidone on gastrointestinal action.

If women choose this drug throughout pregnancy, there is a hazard that their new child infants will practical experience neonatal withdrawal syndrome.

Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of your medicinal merchandise is vital.

Hyperalgesia Hyperalgesia might be diagnosed In case the individual on long-expression opioid therapy presents with increased agony.

Codeine could impair mental and/or physical capabilities essential with the efficiency of doubtless dangerous duties such as driving a car or truck or functioning machinery. These responsibilities need to be averted though getting this product.

Supplemental assist and monitoring could be required when prescribing for people vulnerable to opioid misuse.

Codeine can develop drug dependence on the morphine sort click here and, for that reason, has the potential for getting abused. Psychological dependence, Bodily dependence, and tolerance may acquire on repeated administration, and it should be prescribed and administered While using the same diploma of warning ideal to the usage of other oral narcotic drugs.

Domperidone and metoclopramide: codeine antagonises the influence of cisapride, metoclopramide and domperidone on gastrointestinal activity.